Format

Send to

Choose Destination
Best Pract Res Clin Endocrinol Metab. 2018 Nov 3. pii: S1521-690X(18)30120-9. doi: 10.1016/j.beem.2018.10.006. [Epub ahead of print]

Towards complication-free assisted reproduction technology.

Author information

1
IVI-RMA Lisboa, Avenida Infante Dom Henrique 333 H 1-9, 1800-282, Lisbon, Portugal. Electronic address: samueldsribeiro@gmail.com.
2
Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, Brussels 1090, Belgium. Electronic address: shari.mackens@uzbrussel.be.
3
Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, Brussels 1090, Belgium; Academic Unit of Obstetrics and Gynaecology, IRCCS AOU San Martino-IST, University of Genoa, Largo Rosanna Benzi 10, Genova 16132, Italy. Electronic address: annalisa.racca@uzbrussel.be.
4
Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, Brussels 1090, Belgium; Department of Obstetrics and Gynaecology, School of Medicine, University of Zagreb, Šalata 3, Zagreb 10000, Croatia. Electronic address: christophe.blockeel@uzbrussel.be.

Abstract

Assisted reproductive technology (ART) has vastly improved over the last 40 years, from a frequently unsuccessful and complicated procedure requiring hospital admission and routine laparoscopy to a fairly simple outpatient technique with relatively high success rates. However, it is important to stress that ART is not without risk and medical complications may still occur. The incidence of most of these ART-related complications is associated with how women undergo ovarian stimulation. For this reason, physicians should be aware that a carefully thought-out ovarian stimulation protocol and cycle monitoring are of paramount importance to maximise the success of the treatment while avoiding potentially life-threating complications to occur in this frequently otherwise healthy patient population. This review discusses the rationale and evolution of ovarian stimulation strategies over the years and the current developments towards finding a balance between the retrieval of a sufficient number of oocytes and ART-related complication prevention.

KEYWORDS:

assisted reproductive technology; freeze-all strategy; ovarian hyperstimulation syndrome; ovarian stimulation; ovarian torsion; thromboembolism

PMID:
30473208
DOI:
10.1016/j.beem.2018.10.006

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center