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Plant Sci. 2019 Jan;278:113-117. doi: 10.1016/j.plantsci.2018.10.025. Epub 2018 Nov 2.

Mini review: Revisiting mobile RNA silencing in plants.

Author information

1
Research Centre for Plant RNA Signaling, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036, China.
2
Department of Statistics, University of Georgia, Athens, GA 30602, USA.
3
Worcester-Hangzhou Joint Molecular Plant Health Laboratory, Institute of Science and the Environment, University of Worcester, WR2 6AJ, UK.
4
Nitrogen Fixation Laboratory, Qi Institute, Jiaxing 314000, Zhejiang, China.
5
Research Centre for Plant RNA Signaling, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036, China; Worcester-Hangzhou Joint Molecular Plant Health Laboratory, Institute of Science and the Environment, University of Worcester, WR2 6AJ, UK; Warwick-Hangzhou RNA Signaling Joint Laboratory, School of Life Sciences, University of Warwick, Warwick CV4 7AL, UK. Electronic address: yiguo.hong@hznu.edu.cn.

Abstract

Non-cell autonomous RNA silencing can spread from cell to cell and over long-distances in animals and plants. This process is genetically determined and requires mobile RNA signals. Genetic requirement and molecular nature of the mobile signals for non-cell-autonomous RNA silencing were intensively investigated in past few decades. No consensus dogma for mobile silencing can be reached in plants, yet published data are sometimes inconsistent and controversial. Thus, the genetic requirements and molecular signals involved in plant mobile silencing are still poorly understood. This article revisits our present understanding of intercellular and systemic non-cell autonomous RNA silencing, and summarises current debates on RNA signals for mobile silencing. In particular, we discuss new evidence on siRNA mobility, a DCL2-dependent genetic network for mobile silencing and its potential biological relevance as well as 22 nt siRNA being a mobile signal for non-cell-autonomous silencing in both Arabidopsis and Nicotiana benthamiana. This sets up a new trend in unravelling genetic components and small RNA signal molecules for mobile silencing in (across) plants and other organisms of different kingdoms. Finally we raise several outstanding questions that need to be addressed in future plant silencing research.

KEYWORDS:

DICER-LIKEs; Intercellular RNA silencing; Mobile silencing signal; Small interfering RNA (siRNA); Systemic RNA silencing

PMID:
30471724
PMCID:
PMC6556431
DOI:
10.1016/j.plantsci.2018.10.025
[Indexed for MEDLINE]
Free PMC Article

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