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Int J Gynaecol Obstet. 2019 Feb;144(2):174-179. doi: 10.1002/ijgo.12723. Epub 2018 Dec 7.

Doppler ultrasonographic assessment of fetal middle cerebral artery peak systolic velocity in gestational diabetes mellitus.

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Department of Postgraduate Studies in Health and the Environment, University of the Region of Joinville, Joinville, Brazil.
Department of Medicine, University of the Region of Joinville, Joinville, Brazil.
High Risk Sector, Hospital Maternidade Darcy Vargas, Joinville, Brazil.



To compare Doppler ultrasonographic measurements of the fetal middle cerebral artery peak systolic velocity (MCA PSV) among women with or without gestational diabetes mellitus (GDM).


A cross-sectional study was conducted among pregnant women who presented for prenatal care at a single hospital in Brazil between September 11, 2015, and January 6, 2017. Patients were stratified into a group with GDM and a control group without GDM. One Doppler ultrasonographic assessment was performed per participant. This measurement was made after diagnosis but before the start of treatment among women in the GDM group. Fetal ultrasonographic and biometric variables assessed included MCA PSV, MCA pulsatility index, umbilical artery pulsatility index, the MCA-to-umbilical artery ratio, abdominal circumference, and weight.


The study included 238 women: 115 in the GDM group and 123 in the control group. The median MCA PSV was 1.02 in the GDM group and 1.08 in the control group (P=0.036). No statistically significant between-group differences were found for the other fetal ultrasonographic variables or for the fetal biometric variables assessed. None of the maternal or fetal parameters assessed displayed a linear correlation with MCA PSV.


Doppler ultrasonographic measurements of MCA PSV were lowered among the fetuses of women diagnosed with GDM.


Doppler ultrasonography; Fetal wellbeing; Gestational diabetes mellitus; Middle cerebral artery; Peak systolic velocity; Ultrasonography

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