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Adv Exp Med Biol. 2018;1064:237-251. doi: 10.1007/978-981-13-0445-3_15.

ROS-Responsive Biomaterial Design for Medical Applications.

Author information

1
Department of Biomedical Science, Yonsei University College of Medicine, Seoul, South Korea.
2
Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.
3
Department of Biomedical Science, Yonsei University College of Medicine, Seoul, South Korea. hj72sung@yuhs.ac.

Abstract

Stimuli-responsive biomaterials undergo significant alterations in material structure and property in response to changes of local environmental factors (e.g. pH, temperature, enzyme activation, and water absorption). In particular, reactive oxygen species (ROS) is considered as a major stimulus because over-production of ROS involves most types of major pathogenesis. The application of ROS-responsive biomaterials requires suitable material designs to program user-defined changes of their structure and property in response to a sudden change in the local ROS level. This chapter summarizes the progress in designing and applying major types of ROS-responsive biomaterials within the past 10 years.

KEYWORDS:

Biomaterials; Pathogenesis; Reactive oxygen species; Smart function; Stimuli-responsive

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