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Trends Cancer. 2018 Dec;4(12):802-809. doi: 10.1016/j.trecan.2018.10.002. Epub 2018 Oct 24.

The Multiple Layers of the Tumor Environment.

Author information

1
IHPST, CNRS UMR 8590, Paris, France; Institut Gustave Roussy, UMR 8590, France.
2
ImmunoConcept, CNRS UMR 5164, Bordeaux, France; University of Bordeaux, Bordeaux, France.
3
ImmunoConcept, CNRS UMR 5164, Bordeaux, France; University of Bordeaux, Bordeaux, France; Co-last authors. Electronic address: thomas.pradeu@u-bordeaux.fr.
4
IHPST, CNRS UMR 8590, Paris, France; University of Bordeaux, Bordeaux, France; LAMC-INSERM U1029, Bordeaux, France; Co-last authors. Electronic address: andreas.bikfalvi@u-bordeaux.fr.

Abstract

The notion of tumor microenvironment (TME) has been brought to the forefront of recent scientific literature on cancer. However, there is no consensus on how to define and spatially delineate the TME. We propose that the time is ripe to go beyond an all-encompassing list of the components of the TME, and to construct a multilayered view of cancer. We distinguish six layers of environmental interactions with the tumor and show that they are associated with distinct mechanisms, and ultimately with distinct therapeutic approaches.

KEYWORDS:

angiogenesis; immune system; niche; tumor microenvironment; tumor organismal environment

PMID:
30470302
DOI:
10.1016/j.trecan.2018.10.002
[Indexed for MEDLINE]

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