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Nanomaterials (Basel). 2018 Nov 21;8(11). pii: E961. doi: 10.3390/nano8110961.

Design and Evaluation of Europium Containing Mesoporous Bioactive Glass Nanospheres: Doxorubicin Release Kinetics and Inhibitory Effect on Osteosarcoma MG 63 Cells.

Author information

1
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215023, China. yingzhang@suda.edu.cn.
2
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215023, China. mhu777@stu.suda.edu.cn.
3
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215023, China. 20184209228@stu.suda.edu.cn.
4
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215023, China. zhouzhufa@suda.edu.cn.
5
National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215023, China. liuyu@suda.edu.cn.

Abstract

Functional ions and drug factors play a vital role in stimulating bone tissue regeneration as we understand it. In this work, europium-containing mesoporous bioactive glass nanospheres (Eu/MBGs), composed of 60% SiO₂-(36⁻x)%CaO-x%Eu₂O₃-4%P₂O₅ (x = 0, 0.5, 1, 2 mol%), were prepared by a facile sol-gel process. The results indicate that Eu ions play an important role to influence the microstructure of MBGs, in which a suitable concentration of Eu (1 mol%) increases their surface area (502 m²/g) as well as their pore volume (0.34 cm³/g). Proper doping of Eu ions in MBGs can observably induce apatite mineralization and improve the doxorubicin (DOX) release behavior. Furthermore, DOX-loaded Eu/MBGs could maintain a long-term inhibitory effect on the viability of osteosarcoma MG 63 cells. This work has demonstrated that it is possible to develop functional Eu/MBGs by combining excellent apatite-mineralization ability, controllable drug (DOX) release and antitumor functions for the therapy of bone tissue regeneration.

KEYWORDS:

drug release; europium; mesoporous bioactive glass nanospheres; osteosarcoma MG 63 cells

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