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Int J Pharm. 2019 Jan 30;555:146-152. doi: 10.1016/j.ijpharm.2018.11.054. Epub 2018 Nov 22.

Chitosan/Copaiba oleoresin films for would dressing application.

Author information

1
Laboratório de Biotecnologia de Produtos Naturais (BIONAT), Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Rua São Nicolau, 210, Diadema - SP, CEP 09913-030, Brazil.
2
Universidade Tiradentes (Unit), Av. Murilo Dantas, 300, Farolândia, Aracaju CEP 49.032-490, Brazil; Instituto de Tecnologia e Pesquisa, Laboratório de Nanotecnologia e Nanomedicina (LNMed) Av. Murilo Dantas, 300, Aracaju CEP 49.032-490, Brazil.
3
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; CEB - Centre of Biological Engineering, University of Minho, Campus de Gualtar 4710-057 Braga, Portugal. Electronic address: ebsouto@ff.uc.pt.
4
Laboratório de Biotecnologia de Produtos Naturais (BIONAT), Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Rua São Nicolau, 210, Diadema - SP, CEP 09913-030, Brazil. Electronic address: cfsilva@unifesp.br.

Abstract

Biopolymeric films can be used as dressings for the treatment of skin burns and other chronic wounds. The healing properties of these films may be enhanced by the addition of Copaiba oil (Copaifera L.) which properties have already been well-described. The aim of this study was to evaluate the addition of Copaiba oil in chitosan films prepared by casting solvent evaporation technique using chitosan solution (2% or 1% wt/wt) and Copaiba oil (0.1 or 1.0% wt/wt) at different concentrations. Films were characterized by color analysis, scanning electron microscopy, mechanical properties, thermal analysis, and fluid handling capacity. The developed films demonstrated potential for wound dressing, translated by the fluid handling capacity similar to that of commercial dressings. While no surfactant was present in the formulation, the droplets of Copaiba oil were well-dispersed and homogeneously distributed in the chitosan matrix even after drying. The thermal analysis translated the occurrence of interactions between the oil and chitosan.

KEYWORDS:

Chitosan; Copaiba oil; Copaifera L.; Films; Wound dressings

PMID:
30468843
DOI:
10.1016/j.ijpharm.2018.11.054
[Indexed for MEDLINE]

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