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Per Med. 2019 Jan;16(1):35-49. doi: 10.2217/pme-2018-0045. Epub 2018 Nov 23.

MTHFR polymorphisms as risk for male infertility in Pakistan and its comparison with socioeconomic status in the world.

Author information

1
Institute of Biomedical & Genetic Engineering (IB & GE), 24 Mauve Area, G9/1, Islamabad 44000, Pakistan.
2
Department of Biochemistry, Quaid-i-Azam University, Islamabad 44000, Pakistan.
3
Department of Biosciences, COMSATS Institute of Technology, Park Road, Chak Shahzad, Islamabad 44000, Pakistan.

Abstract

AIM:

5,10-MTHFR-single nucleotide polymorphisms are important for normal functioning of the enzyme that plays a key role in DNA synthesis, folate metabolism and methylation reactions. Methodology & results: Male infertility association of C665T and A1298C polymorphisms was explored, this topic is still debatable. Infertile men (232) and controls (114) were genotyped and statistically analyzed. Comparison of patients (6180) and controls (5744) of Caucasian populations was performed by meta-analysis. Pooled results showed A1298C minor allele and homozygous genotype to be of a significantly higher frequency in the low-income group. Increase in per capita income has shown an increasing trend in the minor allele frequency in various world populations, potentially due to dietry-folate compensation.

CONCLUSION:

A1298C seems more relevant marker than C665T for infertility association in Caucasian populations and may be addressed by improving dietary folate.

KEYWORDS:

; A1298C; C665T; Caucasian; Pakistani population; folate deficiency; male-infertilty; meta-analysis; polymorphism association; socioeconomic status

PMID:
30468411
DOI:
10.2217/pme-2018-0045
[Indexed for MEDLINE]

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