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Science. 2018 Nov 23;362(6417):949-952. doi: 10.1126/science.aat8642.

Molecular to organismal chirality is induced by the conserved myosin 1D.

Author information

1
Université Côte D'Azur, CNRS, Inserm, Institut de Biologie Valrose, Nice, France.
2
Pennsylvania Muscle Institute and the Center for Engineering Mechanobiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
3
Université Côte D'Azur, CNRS, Inserm, Institut de Biologie Valrose, Nice, France. noselli@unice.fr.

Abstract

The emergence of asymmetry from an initially symmetrical state is a universal transition in nature. Living organisms show asymmetries at the molecular, cellular, tissular, and organismal level. However, whether and how multilevel asymmetries are related remains unclear. In this study, we show that Drosophila myosin 1D (Myo1D) and myosin 1C (Myo1C) are sufficient to generate de novo directional twisting of cells, single organs, or the whole body in opposite directions. Directionality lies in the myosins' motor domain and is swappable between Myo1D and Myo1C. In addition, Myo1D drives gliding of actin filaments in circular, counterclockwise paths in vitro. Altogether, our results reveal the molecular motor Myo1D as a chiral determinant that is sufficient to break symmetry at all biological scales through chiral interaction with the actin cytoskeleton.

PMID:
30467170
DOI:
10.1126/science.aat8642

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