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Med Clin North Am. 2019 Jan;103(1):137-152. doi: 10.1016/j.mcna.2018.08.006.

Irritable Bowel Syndrome: What Treatments Really Work.

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Department of Medicine, Division of Gastroenterology, King Khalid University Hospital, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi Arabia.
Department of Medicine, Division of Gastroenterology, Johns Hopkins University, 4940 Eastern Avenue, 3rd Floor, Baltimore, MD 21224, USA. Electronic address:


Irritable bowel syndrome (IBS) is present in patients with symptoms of chronic abdominal pain and altered bowel habits but no identifiable organic etiology. Rome IV classification groups patients based on predominant stool pattern. Low-FODMAP diets have been helpful in providing symptom relief, as have cognitive behavioral and mind-body techniques that help patients manage symptoms. Targeted symptomatic relief for the patient's predominant symptoms provides relief in addition to effective older medications that are inexpensive and reliable. Newer treatments for IBS-D, such as eluxadoline, and IBS-C, with linaclotide, lubiprostone, plecanatide, also can provide durable relief.


Constipation; Diarrhea; Irritable bowel syndrome (IBS); Rome criteria

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