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Kidney Int. 2018 Dec;94(6):1042-1044. doi: 10.1016/j.kint.2018.09.011.

Awakening the Bowman: inhibition of CXCL12 signaling activates parietal epithelial cells.

Author information

1
Universite Cote d'Azur, iBV, Centre de Biochimie, Nice, France.
2
Universite Cote d'Azur, iBV, Centre de Biochimie, Nice, France. Electronic address: Schedl@unice.fr.

Abstract

Glomerular podocytes are terminally differentiated cells, and podocyte loss is a common feature of progressive renal pathologies. In this issue, Romoli et al. focus on podocyte progenitors that were proposed to reside in the Bowman's capsule. They demonstrate that suppression of CXCL12/CXCR4 signaling activates parietal epithelial cells that integrate into glomeruli, express podocyte specific markers, and interdigitate with existing cells. The data may open new therapeutic avenues for the treatment of glomerular diseases.

PMID:
30466560
DOI:
10.1016/j.kint.2018.09.011
[Indexed for MEDLINE]

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