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Alzheimers Dement. 2019 Jan;15(1):8-16. doi: 10.1016/j.jalz.2018.07.215. Epub 2018 Dec 11.

Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease.

Author information

1
Department of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
2
Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
3
Department of Neurology, Duke University School of Medicine, Durham, NC, USA.
4
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
5
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
6
Department of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: troncoso@jhmi.edu.

Abstract

INTRODUCTION:

Primary age-related tauopathy (PART) is a recently described entity that can cause cognitive impairment in the absence of Alzheimer's disease (AD). Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and cognitive profiles in age-matched subjects with PART and AD pathology.

METHODS:

Brain autopsies (n = 183) were conducted on participants 85 years and older from the Baltimore Longitudinal Study of Aging and Johns Hopkins Alzheimer's Disease Research Center. Participants, normal at enrollment, were followed with periodic cognitive evaluations until death.

RESULTS:

Compared with AD, PART subjects showed significantly slower rates of decline on measures of memory, language, and visuospatial performance. They also showed lower APOE ε4 allele frequency (4.1% vs. 17.6%, P = .0046).

DISCUSSION:

Our observations suggest that PART is separate from AD and its distinction will be important for the clinical management of patients with cognitive impairment and for public health care planning.

KEYWORDS:

Aging; Alzheimer disease (AD); Dementia; Mild Cognitive Impairment (MCI); Neurofibrillary tangles; Primary Age-Related Tauopathy (PART); Public Health Planning

PMID:
30465754
DOI:
10.1016/j.jalz.2018.07.215

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