Send to

Choose Destination
ACS Appl Mater Interfaces. 2018 Dec 19;10(50):43396-43404. doi: 10.1021/acsami.8b15064. Epub 2018 Dec 4.

Cu-Fe-Se Ternary Nanosheet-Based Drug Delivery Carrier for Multimodal Imaging and Combined Chemo/Photothermal Therapy of Cancer.

Author information

Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) , Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Suzhou 215123 , China.


Ternary transition-metal chalcogenide nanosheets have shown great potential in diverse applications owing to their intrinsically amazing properties with a broad tunable window. Direct preparation of water-soluble and biocompatible ternary chalcogenide nanosheets for theranostic application remains a challenge. In this article, we prepared Cu-Fe-Se nanosheets (CFS NSs) in an aqueous solution under ambient conditions by a sequential coprecipitation method. They were functionalized with anticancer drug doxorubin (CFS@DOX) through electrostatic interactions and labeled with radioactive isotope 99mTc through surface coordination effect. The resulting nanosheets have a size of 70 nm and a thickness of 5 nm, and can be well dispersed in water, phosphate-buffered saline, 10% fetal bovine serum, and 0.9% NaCl with an excellent colloidal stability. They also exhibit a high photothermal conversion efficiency of 78.9% for in vitro and in vivo photoacoustic imaging and photothermal therapy. The isotope-labeled nanosheets (99mTc-CFS NSs) were used for single photon emission computed tomography/computed tomography imaging to quantify their blood circulation time (∼4.7 h) and biodistributions in major organs, which follow an order of liver > bladder > lung > spleen > heart > kidney. The DOX-functionalized nanosheets (CFS@DOX) were used for chemotherapy of cancer and exhibited excellent anticancer efficacy. Our research shows the great promise of ternary metal chalcogenide nanosheets for combined imaging and therapy of cancer.


chemotherapy; multimodal imaging; photothermal therapy; radiolabeling; transition-metal chalcogenides; two-dimensional ternary nanosheets

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center