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J Comp Eff Res. 2019 Jan;8(2):91-102. doi: 10.2217/cer-2018-0115. Epub 2018 Nov 22.

Efficacy of gelatin tannate for acute diarrhea in children: a systematic review and meta-analysis.

Author information

1
Pediatric Gastroenterology & Liver Unit, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
2
Department of Pediatrics, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.

Abstract

AIM:

To investigate by meta-analysis the efficacy of gelatin tannate (GT), a mucosal barrier protector, in children with acute gastroenteritis.

METHODS:

A comprehensive literature search was conducted. Studies were selected according to PICO: Participants: children aged 0-12 years with acute diarrhea; Intervention: GT; Comparison: oral rehydration solution and/or placebo; Outcomes: diarrhea-related outcomes.

RESULTS:

Three published randomized controlled trials were identified of pediatric diarrhea treated with GT (n = 203) or control (n = 204). GT significantly (p < 0.01) reduced stool frequency at 12 h in two randomized controlled trials. A significant treatment effect (risk ratio = 0.74; p < 0.01) in favor of GT was found for the exploratory composite outcome of 'diarrhea or liquid stools at 24 h' in three studies. Risk ratios in a single study which reported the percentage of patients with liquid stools at 12, 24 and 48 h favored GT at all time points. No significant differences were found between GT and control for patients with diarrhea at 12 or 24 h or for duration of diarrhea.

CONCLUSION:

GT improved stool frequency and stool consistency in children with acute diarrhea, although further well-controlled studies would be useful to confirm a beneficial treatment effect.

KEYWORDS:

diarrhea; gelatin tannate; meta-analysis; pediatrics

PMID:
30465439
DOI:
10.2217/cer-2018-0115

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