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J Comp Eff Res. 2019 Jan;8(2):91-102. doi: 10.2217/cer-2018-0115. Epub 2018 Nov 22.

Efficacy of gelatin tannate for acute diarrhea in children: a systematic review and meta-analysis.

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Pediatric Gastroenterology & Liver Unit, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
Department of Pediatrics, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.



To investigate by meta-analysis the efficacy of gelatin tannate (GT), a mucosal barrier protector, in children with acute gastroenteritis.


A comprehensive literature search was conducted. Studies were selected according to PICO: Participants: children aged 0-12 years with acute diarrhea; Intervention: GT; Comparison: oral rehydration solution and/or placebo; Outcomes: diarrhea-related outcomes.


Three published randomized controlled trials were identified of pediatric diarrhea treated with GT (n = 203) or control (n = 204). GT significantly (p < 0.01) reduced stool frequency at 12 h in two randomized controlled trials. A significant treatment effect (risk ratio = 0.74; p < 0.01) in favor of GT was found for the exploratory composite outcome of 'diarrhea or liquid stools at 24 h' in three studies. Risk ratios in a single study which reported the percentage of patients with liquid stools at 12, 24 and 48 h favored GT at all time points. No significant differences were found between GT and control for patients with diarrhea at 12 or 24 h or for duration of diarrhea.


GT improved stool frequency and stool consistency in children with acute diarrhea, although further well-controlled studies would be useful to confirm a beneficial treatment effect.


diarrhea; gelatin tannate; meta-analysis; pediatrics


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