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J Bone Miner Metab. 2018 Nov 21. doi: 10.1007/s00774-018-0974-4. [Epub ahead of print]

Re-fracture and correlated risk factors in patients with osteoporotic vertebral fractures.

Author information

1
School of Nursing, Fudan University, Shanghai, 200032, China.
2
School of Nursing, Fudan University, Shanghai, 200032, China. hsxia@fudan.edu.cn.
3
Youjiang Medical University for Nationalities, Baise, 533000, China.
4
West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, 610041, China.
5
The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.

Abstract

Re-fracture risk is higher following osteoporotic fracture. However, there is no accurately reported rate of re-fracture incidence in southwest China. The purpose of this study was to describe the osteoporotic vertebral fracture (OVF) survival for re-fracture state and analyze the risk of re-fracture. This historical cohort study was conducted in four hospitals in southwest China. Patients aged ≥ 50 years (n = 586) with OVF who were supposed to receive anti-osteoporosis drugs after the fracture were included (2012-2017). Telephone follow-up and referring case files were used to estimate the survival for re-fracture and identify the determinants of re-fracture. A total of 555 patients completed the follow-up investigation. Overall, 285 patients experienced a re-fracture, and the longest follow-up investigation time was 72 months. The survival rates for re-fracture at 12 months, 24 months, 36 months, and 48 months were 82.0%, 71.5%, 61.7%, and 34.0%, respectively. The factors correlated with re-fracture hazard were advanced age [hazard ratio (HR) = 1.996], being female (HR = 1.342), smoking (HR = 1.435), history of hypertension (HR = 1.219) and diabetes (HR = 3.271), and persistence of taking anti-osteoporosis drugs after fracture [0-3 months, 4-6 months, 7-12 months, and more than 12 months (HR = 0.703)]. OVF patients with advanced age, who were female, smoked, had fracture with hypertension or diabetes, and who complied poorly with anti-osteoporosis drug treatment presented higher prevalence of re-fracture and low anti-osteoporosis adherence in southwest China. The management of anti-osteoporosis after fracture is necessary in this area.

KEYWORDS:

Anti-osteoporosis; Osteoporosis; Osteoporotic vertebral fracture; Re-fracture

PMID:
30465091
DOI:
10.1007/s00774-018-0974-4

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