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Diabetologia. 2019 Feb;62(2):223-232. doi: 10.1007/s00125-018-4777-x. Epub 2018 Nov 21.

The many secret lives of adipocytes: implications for diabetes.

Author information

1
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-8549, USA. Philipp.Scherer@utsouthwestern.edu.

Abstract

Adipose tissue remains a cryptic organ. The ubiquitous presence of adipocytes, the different fat pads in distinct anatomical locations, the many different types of fat, in each case with their distinct precursor populations, and the ability to interchange into other types of fat cells or even de-differentiate altogether, offers a staggering amount of complexity to the adipose tissue organ as a whole. Adipose tissue holds the key to improving our understanding of systemic metabolic homeostasis. As such, understanding adipose tissue physiology offers the basis for a mechanistic understanding of the pathophysiology of diabetes. This review presents some of the lesser known aspects of this fascinating tissue, which consistently still offers much opportunity for the discovery of novel targets for pharmacological intervention.

KEYWORDS:

Adipokines; Adiponectin; Ceramides; De-differentiation; Exosomes; Fibrosis; Inflammation; Review; Sphingolipids; Vascularisation

PMID:
30465066
PMCID:
PMC6324990
[Available on 2020-02-01]
DOI:
10.1007/s00125-018-4777-x
[Indexed for MEDLINE]

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