Format

Send to

Choose Destination
Sci Rep. 2018 Nov 21;8(1):17155. doi: 10.1038/s41598-018-34840-7.

Anti-obesity activity of OBEX is regulated by activation of thermogenesis and decreasing adiposity gain.

Author information

1
Lab de Endocrinología Molecular, Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS), Complejo Hospitalario de Santiago (CHUS), A Coruña, Spain.
2
CIBER Fisiopatología Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
3
Clinical and Experimental Endocrinology, Unit for Multidisciplinary Research in Biomedicine UMIB, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto, Porto, Portugal.
4
Lab de Endocrinología Molecular, Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS), Complejo Hospitalario de Santiago (CHUS), A Coruña, Spain. anabelencrujeiras@hotmail.com.
5
CIBER Fisiopatología Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain. anabelencrujeiras@hotmail.com.
6
Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigacion Sanitaria, A Coruña, Spain.
7
Grupo Fisiopatologia Endocrina, Instituto de Investigación Sanitaria de Santiago de Compostela, Complexo, Hospitalario Universitario de Santiago (CHUS/SERGAS), Santiago de Compostela, Spain.
8
Catalysis S.L., Madrid, Spain.
9
Lab de Endocrinología Molecular, Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS), Complejo Hospitalario de Santiago (CHUS), A Coruña, Spain. endocrine@usc.es.
10
CIBER Fisiopatología Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain. endocrine@usc.es.
11
Universidad de Santiago de Compostela (USC), Santiago de Compostela, Spain. endocrine@usc.es.

Abstract

The incidence of obesity has been increasing dramatically worldwide over the past decades, thus requiring novel and effective therapeutic approaches. OBEX is an oral nutritional supplement composed of antioxidants with antiobesity activity. The effects of OBEX have been tested in vivo and in vitro. In vivo, OBEX reduces weight gain by decreasing adiposity gain and increasing energy expenditure in high fat diet-fed mice through the activation of thermogenesis in brown adipose tissue (BAT) independent of eating behaviors. In vitro analysis with 3T3-F442A cells revealed anti-proliferative and anti-differentiation effects of OBEX. In addition, OBEX induced a clear reduction of the lipid load in mature adipocytes obtained from 3T3-F442A cells. Overall, our findings suggest that OBEX has a protective effect against an obesogenic environment.

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center