Format

Send to

Choose Destination
Nat Rev Neurosci. 2019 Jan;20(1):34-48. doi: 10.1038/s41583-018-0091-3.

Mitochondria as central regulators of neural stem cell fate and cognitive function.

Author information

1
Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology (OISB), University of Ottawa, Ottawa, Ontario, Canada.
2
Department of Cellular and Molecular Medicine, University of Ottawa Brain and Mind Research Institute, Ottawa, Ontario, Canada.
3
Department of Cellular and Molecular Medicine, University of Ottawa Brain and Mind Research Institute, Ottawa, Ontario, Canada. rslack@uottawa.ca.

Abstract

Emerging evidence now indicates that mitochondria are central regulators of neural stem cell (NSC) fate decisions and are crucial for both neurodevelopment and adult neurogenesis, which in turn contribute to cognitive processes in the mature brain. Inherited mutations and accumulated damage to mitochondria over the course of ageing serve as key factors underlying cognitive defects in neurodevelopmental disorders and neurodegenerative diseases, respectively. In this Review, we explore the recent findings that implicate mitochondria as crucial regulators of NSC function and cognition. In this respect, mitochondria may serve as targets for stem-cell-based therapies and interventions for cognitive defects.

PMID:
30464208
DOI:
10.1038/s41583-018-0091-3

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center