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Drug Discov Ther. 2018;12(5):309-314. doi: 10.5582/ddt.2018.01056.

Successful treatment of repeated hematemesis secondary to postsclerotherapy esophageal ulcer in a cirrhotic patient: A case report.

Bai Z1,2, Guo X1, Shao X1, Li Y1,3, Li Q1,4, Xu X1,2, Liang Z1, Deng J5, Zhang X6, Li H1, Qi X1.

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Department of Gastroenterology, General Hospital of Shenyang Military Area.
Postgraduate College, Shenyang Pharmaceutical University.
Postgraduate College, Jinzhou Medical University.
Postgraduate College, Dalian Medical University.
Department of Pharmacology, General Hospital of Shenyang Military Area.
No. 4 People Hospital of Shenyang City.


Esophageal variceal bleeding is a common lethal complication of cirrhosis. Endoscopic injection sclerotherapy (EIS) is one of the major endoscopic approaches for treating esophageal variceal bleeding. However, complications may occur after EIS, which mainly include retrosternal discomfort/pain, dysphagia, re-bleeding, esophageal ulcer, esophageal strictures, and esophageal perforation, etc. In this article, we reported a 36-year-old male who developed esophageal ulcer related bleeding after EIS. Currently, there is no consensus on the treatment strategy for esophageal ulcer-related bleeding after EIS. In the present case, the following treatment strategy may be effective for ulcer related bleeding. The first step is to inhibit gastric acid secretion and reduce portal pressure by intravenous infusion of esomeprazole and somatostatin, respectively. The second is local hemostasis by oral norepinephrine and lyophilizing thrombin powder. The third is to protect digestive tract mucosa by oral Kangfuxin Ye and aluminum phosphate.


Esophageal varices; endoscopic band ligation; endoscopic injection sclerotherapy; esophageal ulcer; portal hypertension

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