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Nutrients. 2018 Nov 19;10(11). pii: E1800. doi: 10.3390/nu10111800.

Molecular Fingerprints of Iron Parameters among a Population-Based Sample.

Author information

1
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany. anne.kaul@gmx.de.
2
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany. annette.masuch@uni-greifswald.de.
3
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany. kathrin.budde@uni-greifswald.de.
4
German Center for Cardiovascular Disease (DZHK e.V.), partner site Greifswald, 17475 Greifswald, Germany. kathrin.budde@uni-greifswald.de.
5
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, 85764 Neuherberg, Germany. g.kastenmueller@helmholtz-muenchen.de.
6
Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, 85764 Neuherberg, Germany. anna.artati@helmholtz-muenchen.de.
7
Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, 85764 Neuherberg, Germany. adamski@helmholtz-muenchen.de.
8
Lehrstuhl für Experimentelle Genetik, Technische Universität München, 85354 Freising-Weihenstephan, Germany. adamski@helmholtz-muenchen.de.
9
DZD (German Center for Diabetes Research), 85764 München-Neuherberg, Germany. adamski@helmholtz-muenchen.de.
10
German Center for Cardiovascular Disease (DZHK e.V.), partner site Greifswald, 17475 Greifswald, Germany. voelzke@uni-greifswald.de.
11
Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany. voelzke@uni-greifswald.de.
12
DZD (German Center for Diabetes Research), site Greifswald, 17475 Greifswald, Germany. voelzke@uni-greifswald.de.
13
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany. matthias.nauck@uni-greifswald.de.
14
German Center for Cardiovascular Disease (DZHK e.V.), partner site Greifswald, 17475 Greifswald, Germany. matthias.nauck@uni-greifswald.de.
15
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany. nele.friedrich@uni-greifswald.de.
16
German Center for Cardiovascular Disease (DZHK e.V.), partner site Greifswald, 17475 Greifswald, Germany. nele.friedrich@uni-greifswald.de.
17
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany. maik.pietzner@uni-greifswald.de.
18
German Center for Cardiovascular Disease (DZHK e.V.), partner site Greifswald, 17475 Greifswald, Germany. maik.pietzner@uni-greifswald.de.

Abstract

Iron deficiency is the most frequent deficiency disease and parameters of iron metabolism appear to be linked to major metabolic and cardiovascular diseases. We screened a large set of small molecules in plasma for associations with iron status among apparently healthy subjects to elucidate subclinical profiles which may provide a link between iron status and onset of diseases. Based on mass spectrometry and nuclear magnetic resonance spectroscopy we determined 613 plasma metabolites and lipoprotein subfractions among 820 apparently healthy individuals. Associations between ferritin, transferrin, haemoglobin and myoglobin and metabolite levels were tested by sex-specific linear regression analyses controlling for common confounders. Far more significant associations in women (82 out of 102) compared to men became obvious. The majority of the metabolites associated with serum ferritin and haemoglobin in women comprising fatty acid species, branched-chain amino acid catabolites and catabolites of heme. The latter was also obvious among men. Positive associations between serum transferrin and VLDL and IDL particle measures seen in women were observed in men with respect to serum ferritin. We observed a sexual-dimorphic fingerprint of surrogates of iron metabolism which may provide a link for the associations between those parameters and major metabolic and cardiovascular disease.

KEYWORDS:

iron surrogates; lipoprotein profiling; metabolomics

PMID:
30463274
PMCID:
PMC6266982
DOI:
10.3390/nu10111800
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