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Immunity. 2018 Nov 20;49(5):801-818. doi: 10.1016/j.immuni.2018.10.016.

Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules.

Author information

1
Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK. Electronic address: rick.maizels@glasgow.ac.uk.
2
Leiden University Medical Center, Leiden, the Netherlands. Electronic address: h.h.smits@lumc.nl.
3
Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK. Electronic address: henry.mcsorley@ed.ac.uk.

Abstract

Helminths are extraordinarily successful parasites due to their ability to modulate the host immune response. They have evolved a spectrum of immunomodulatory molecules that are now beginning to be defined, heralding a molecular revolution in parasite immunology. These discoveries have the potential both to transform our understanding of parasite adaptation to the host and to develop possible therapies for immune-mediated disease. In this review we will summarize the current state of the art in parasite immunomodulation and discuss perspectives on future areas for research and discovery.

PMID:
30462997
PMCID:
PMC6269126
DOI:
10.1016/j.immuni.2018.10.016
[Indexed for MEDLINE]
Free PMC Article

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