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Cardiovasc J Afr. 2019 Jan/Feb 23;30(1):e4-e6. doi: 10.5830/CVJA-2018-052. Epub 2018 Nov 20.

Pulmonary thromboendarterectomy in a combined thrombophilia patient.

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Department of Cardiovascular Surgery, Faculty of Medicine, Selcuk University, Konya, Turkey. Email:
Department of Cardiovascular Surgery, Faculty of Medicine, Bezmialem University, Istanbul, Turkey.


Chronic thromboembolic pulmonary hypertension (CTEPH) is a potentially correctable cause of secondary pulmonary hypertension. Surgical treatment remains the primary treatment for patients with CTEPH. Pulmonary thromboendarterectomy (PEA) with deep hypothermic circulatory arrest is the standard and recommended surgical technique for the treatment of these patients. The prevalence of CTEPH after an acute pulmonary thromboembolism (PTE) has been found in various studies to be between 0.6 and 8.8%. Mortality rates in elective PEA cases with CTEPH are reported to be between 1.9 and 4.5%. We report on a 50-year-old female patient with combined inherited thrombophilia, including protein C and protein S deficiencies, who was diagnosed with CTEPH and was successfully treated with pulmonary thromboendarterectomy.


protein S; pulmonary embolism; thromboendarterectomy; protein C

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