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ESC Heart Fail. 2019 Feb;6(1):70-79. doi: 10.1002/ehf2.12359. Epub 2018 Nov 20.

Echocardiographic diastolic function evolution in patients with an anterior Q-wave myocardial infarction: insights from the REVE-2 study.

Ferreira JP1,2,3, Bauters C4,5,6, Eschalier R1,2,7, Lamiral Z1, Fay R1, Huttin O1, Girerd N1,2,8,9, Zannad F1,2,9,10, Pinet F2,4,5, Rossignol P1,2,9,10.

Author information

1
Centre d'Investigation Clinique CIC-P 1433, INSERM, Nancy, France.
2
F-CRIN INI-CRCT, Nancy, France.
3
Department of Physiology, University of Porto, Porto, Portugal.
4
CHU Lille, Lille, France.
5
INSERM U1167, Institut Pasteur de Lille, Université de Lille Nord de France, FHU-REMOD-VHF, Lille, France.
6
Faculté de Médecine de Lille, Lille, France.
7
Department of Cardiology, Université Clermont Auvergne, TGI/ISIT/CaViti, Institut Pascal and CHU Clermont-Ferrand, Clermont-Ferrand, France.
8
Department of Cardiology, CHRU Nancy, Nancy, France.
9
Université de Lorraine, Nancy, France.
10
INSERM U1116, Nancy, France.

Abstract

AIMS:

Myocardial fibrosis plays a key role in the development of adverse left ventricular remodelling after myocardial infarction (MI). This study aimed to determine whether the circulating levels of BNP, collagen peptides, and galectin-3 are associated with diastolic function evolution (both deterioration and improvement) at 1 year after an anterior MI.

METHODS AND RESULTS:

The REVE-2 is a prospective multicentre study including 246 patients with a first anterior Q-wave MI. Echocardiographic assessment was performed at hospital discharge and ±1 year after MI. BNP, galectin-3, and collagen peptides were measured ±1 month after MI. Left ventricular diastolic dysfunction (DD) was defined according to the presence of at least two criteria of echocardiographic parameters: septal e' < 8 cm/s, lateral e' < 10 cm/s, and left atrial volume ≥ 34 mL/m2 . At baseline, 87 (35.4%) patients had normal diastolic function and 159 (64.6%) patients had DD. Follow-up of 61 patients among the 87 patients with normal diastolic function at baseline showed that 22 patients (36%) developed DD at 1 year post-MI. The circulating levels of amino-terminal propeptide of type III procollagen > 6 mg/L [odds ratio (OR) = 5.29; 95% confidence interval (CI) = 1.05-26.66; P = 0.044], galectin-3 > 13 μg/L (OR = 5.99; 95% CI = 1.18-30.45; P = 0.031), and BNP > 82 ng/L (OR = 10.25; 95% CI = 2.36-44.50; P = 0.002) quantified at 1 month post-MI were independently associated with 1 year DD. Follow-up of the 137 patients with DD at baseline among the 159 patients showed that 36 patients (26%) had a normalized diastolic function at 1 year post-MI. Patients with a BNP > 82 ng/L were less likely to improve diastolic function (OR = 0.06; 95% CI = 0.01-0.28; P = 0.0003).

CONCLUSIONS:

The present study suggests that circulating levels of amino-terminal propeptide of type III procollagen, galectin-3, and BNP may be independently associated with new-onset DD in post-MI patients.

KEYWORDS:

Cardiac remodelling; Collagen peptides; Diastolic dysfunction; Galectin-3; Myocardial infarction

PMID:
30460754
PMCID:
PMC6351891
DOI:
10.1002/ehf2.12359
[Indexed for MEDLINE]
Free PMC Article

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