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Ned Tijdschr Tandheelkd. 2018 Nov;125(11):593-601. doi: 10.5177/ntvt.2018.11.18203.

[Medicaments and oral healthcare. Systematic review of the -literature assessing the effect of drugs on the salivary glands].

[Article in Dutch; Abstract available in Dutch from the publisher]

Abstract

in English, Dutch

Evidence-based reviews of drugs causing medication-induced salivary gland dysfunction, such as xerostomia (sensation of oral dryness) and subjective sialorrhea are lacking. To compile a list of medicaments that influence salivary gland function, electronic databases were searched for relevant articles published up to June 2013. A total of 269 papers out of 3,867 records located satisfied the inclusion criteria (relevance, quality of methodology, strength of evidence). A total of 56 active substances with a higher level of evidence and 50 active substances with a moderate level of evidence of causing salivary gland dysfunction are described in this article. While xerostomia was a commonly reported outcome, the objective effect on salivary secretion was rarely measured. Xerostomia was, moreover, mostly reported as a negative side effect instead of the intended effect of that drug. A comprehensive list of medications having documented effects on salivary gland function or symptoms was compiled, which may assist practitioners in assessing patients who complain of dry mouth while taking medications.

PMID:
30457580
DOI:
10.5177/ntvt.2018.11.18203
[Indexed for MEDLINE]

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