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Ned Tijdschr Tandheelkd. 2018 Nov;125(11):593-601. doi: 10.5177/ntvt.2018.11.18203.

[Medicaments and oral healthcare. Systematic review of the -literature assessing the effect of drugs on the salivary glands].

[Article in Dutch; Abstract available in Dutch from the publisher]


in English, Dutch

Evidence-based reviews of drugs causing medication-induced salivary gland dysfunction, such as xerostomia (sensation of oral dryness) and subjective sialorrhea are lacking. To compile a list of medicaments that influence salivary gland function, electronic databases were searched for relevant articles published up to June 2013. A total of 269 papers out of 3,867 records located satisfied the inclusion criteria (relevance, quality of methodology, strength of evidence). A total of 56 active substances with a higher level of evidence and 50 active substances with a moderate level of evidence of causing salivary gland dysfunction are described in this article. While xerostomia was a commonly reported outcome, the objective effect on salivary secretion was rarely measured. Xerostomia was, moreover, mostly reported as a negative side effect instead of the intended effect of that drug. A comprehensive list of medications having documented effects on salivary gland function or symptoms was compiled, which may assist practitioners in assessing patients who complain of dry mouth while taking medications.

[Indexed for MEDLINE]

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