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Skeletal Radiol. 2019 Aug;48(8):1289-1291. doi: 10.1007/s00256-018-3114-2. Epub 2018 Nov 20.

Selective rickets from localized advanced maturation-a case report.

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Department of Radiology ML 5031, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229-3039, USA.


An unusual cause of rickets is illustrated by a patient with infantile multisystem inflammatory disease who, by age 2 years and 4 months, developed striking radiographic and clinical rickets restricted to those joints involved by the inflammatory process. The locally increased vascularity from his inflammation led to increased maturation at those sites so rapid as to override the usual enchondral calcification, thus causing a rickets pattern. Other sites, such as the proximal humeri, lacking any inflammation, showed no increased maturation rate and did not manifest local rickets. Rapid local bone maturation may cause localized rickets.


Advanced bone age; CINCA syndrome; Prieur–Griscelli syndrome; Rickets


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