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Life Sci Alliance. 2018 May 31;1(2):e201800046. doi: 10.26508/lsa.201800046. eCollection 2018 May.

The Arabidopsis homolog of human G3BP1 is a key regulator of stomatal and apoplastic immunity.

Author information

1
Desert Agriculture Initiative, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
2
Department of Biology, Science and Arts College, Rabigh Campus, King Abdulaziz University, Jeddah, Saudi Arabia.
3
Institute of Plant Sciences Paris-Saclay, CNRS, INRA, Université Paris-Sud, Université Evry, Université Paris-Saclay, Orsay, France.
4
Institute of Plant Sciences Paris-Saclay, Paris Diderot, Sorbonne Paris-Cité, Orsay, France.
5
Université Grenoble Alpes, CEA, Inserm, BIG-BGE, Grenoble, France.
6
CNRS, BIG-BGE FR3425, Grenoble, France.

Abstract

Mammalian Ras-GTPase-activating protein SH3-domain-binding proteins (G3BPs) are a highly conserved family of RNA-binding proteins that link kinase receptor-mediated signaling to RNA metabolism. Mammalian G3BP1 is a multifunctional protein that functions in viral immunity. Here, we show that the Arabidopsis thaliana homolog of human G3BP1 negatively regulates plant immunity. Arabidopsis g3bp1 mutants showed enhanced resistance to the virulent bacterial pathogen Pseudomonas syringae pv. tomato. Pathogen resistance was mediated in Atg3bp1 mutants by altered stomatal and apoplastic immunity. Atg3bp1 mutants restricted pathogen entry into stomates showing insensitivity to bacterial coronatine-mediated stomatal reopening. AtG3BP1 was identified as a negative regulator of defense responses, which correlated with moderate up-regulation of salicylic acid biosynthesis and signaling without growth penalty.

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