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Clin Case Rep. 2018 Sep 14;6(11):2061-2069. doi: 10.1002/ccr3.1797. eCollection 2018 Nov.

ReGeneraTing Agents (RGTA®) are a new option to improve amputation outcomes in the recovery of severe hand injuries.

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Dept. of Orthopaedics Faculty of Medicine and Health Sciences University Putra Malaysia Serdang Malaysia.
Hand & Upper Limb Centre Pantai Hospital Kuala Lumpur Kuala Lumpur Malaysia.
OTR3 Paris France.
Laboratory CRRET UPEC 4397/ERL CNRS 9215 Université-Paris-Est-Créteil Créteil France.


CACIPLIQ20® was used to accelerate the healing process and stimulate the viability of flaps and skin grafts, thereby improving amputation outcomes. An excellent range of motion was achieved with hardly any contracture or scarring. Pain relief and reduced sensitivity was noted, while healing of bone and tendon also improved, resulting in functional recovery.


CACIPLIQ; amputation of digits; functional recovery; heparan sulfate mimetic; matrix therapy

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