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Biol Sport. 2018 Jun;35(2):105-109. doi: 10.5114/biolsport.2018.71599. Epub 2017 Nov 23.

AGTR2 and sprint/power performance: a case-control replication study for rs11091046 polymorphism in two ethnicities.

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Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
Department of Basic Biomedical Sciences, Universidad Europea de Madrid, Madrid, Spain.
Sport Technology Research Centre, Volga Region State Academy of Physical Culture, Sport and Tourism, Kazan, Russia.
Laboratory of Molecular Genetics, Kazan State Medical University, Kazan, Russia.
Department of Training Science, Nippon Sport Science University.
Department of Sports and Life Science, National Institute of Fitness and Sports in Kanoya, Kagoshima, Japan.
Department of Physical Activity Research; National Institute of Health and Nutrition, NIBIOHN, Japan.
Department of Physical Education, Academy of Physical Education and Sport, Gdansk, Poland.
Department of Physical Culture and Health Promotion, University of Szczecin, Szczecin, Poland.
Department of Molecular Biology and Genetics, Federal Research and Clinical Centre of Physical-Chemical Medicine, Moscow, Russia.
Department of Tourism and Recreation, Academy of Physical Education and Sport, Gdansk, Poland.
Institute of Sport - National Research Institute, Warsaw, Poland.
Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, St Petersburg, Russia.


We aimed to replicate, in a specific athletic event cohort (only track and field) and in two different ethnicities (Japanese and East European, i.e. Russian and Polish), original findings showing the association of the angiotensin-II receptor type-2 gene (AGTR2) rs11091046 A>C polymorphism with athlete status. We compared genotypic frequencies of the AGTR2 rs11091046 polymorphism among 282 track and field sprint/power athletes (200 men and 82 women), including several national record holders and Olympic medallists (214 Japanese, 68 Russian and Polish), and 2024 control subjects (842 men and 1182 women) (804 Japanese, 1220 Russian and Polish). In men, a meta-analysis from the two combined cohorts showed a significantly higher frequency of the C allele in athletes than in controls (odds ratio: 1.62, P=0.008, heterogeneity index I 2 =0%). With regard to respective cohorts, C allele frequency was higher in Japanese male athletes than in controls (67.7% vs. 55.9%, P=0.022), but not in Russian/Polish male athletes (61.9% vs. 51.0%, P=0.172). In women, no significant results were obtained by meta-analysis for the two cohorts combination (P=0.850). The AC genotype frequency was significantly higher in Russian/Polish women athletes than in controls (69.2% vs. 42.1%, P=0.022), but not in Japanese women athletes (P=0.226). Our results, in contrast to previous findings, suggested by meta-analysis that the C allele of the AGTR2 rs11091046 polymorphism is associated with sprint/power track and field athlete status in men, but not in women.


AGTR2; Physical performance; Power; Renin-angiotensin system; Sprint; Track and field

Conflict of interest statement

The authors have no conflicts of interest to declare.

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