Send to

Choose Destination
Trends Cell Biol. 2018 Nov 16. pii: S0962-8924(18)30185-5. doi: 10.1016/j.tcb.2018.10.005. [Epub ahead of print]

Membrane-Associated RNA-Binding Proteins Orchestrate Organelle-Coupled Translation.

Author information

Heidelberg University, Biochemistry Center, Cluster of Excellence CellNetworks, 69120 Heidelberg, Germany.
Eberhard-Karls-University Tübingen, Interfaculty Institute of Biochemistry, Hoppe-Seyler-Straße 4, 72076 Tübingen, Germany.
Heinrich-Heine University Düsseldorf, Institute for Microbiology, Cluster of Excellence on Plant Sciences, 40204 Düsseldorf, Germany. Electronic address:
Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany. Electronic address:


Proteins are positioned and act at defined subcellular locations. This is particularly important in eukaryotic cells that deliver proteins to membrane-bound organelles such as the endoplasmic reticulum (ER), mitochondria, or endosomes. It is axiomatic that organelle targeting depends mainly on polypeptide signals. However, recent results demonstrate that targeting elements within the encoding transcripts are essential for efficient protein localisation. Key readers of these elements are membrane-associated RNA-binding proteins (memRBPs) that orchestrate organelle-coupled translation. The translation products then either cross the membrane for organelle entry or hitchhike on organelle surfaces for complex assembly and co-transport. Understanding the interaction of protein- and RNA-based targeting signals is essential to decipher the molecular basis for mutant phenotypes in disease.


3′ untranslated region; endoplasmic reticulum; endosomes; local translation; mitochondria; organelle


Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center