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Int J Mol Sci. 2018 Nov 16;19(11). pii: E3624. doi: 10.3390/ijms19113624.

Botanical Therapeutics: Phytochemical Screening and Biological Assessment of Chamomile, Parsley and Celery Extracts against A375 Human Melanoma and Dendritic Cells.

Author information

1
Faculty of Pharmacy, "Victor Babeş" University of Medicine and Pharmacy, 300041 Timişoara, Romania. corina.danciu@umft.ro.
2
Faculty of Pharmacy, University of Szeged, H-6720 Szeged, Hungary. zupko@pharm.u-szeged.hu.
3
Faculty of Pharmacy, University of Szeged, H-6720 Szeged, Hungary. andrea.bor@pharm.u-szeged.hu.
4
Pharmazentrum frankfurt/ZAFES, Clinic of the Goethe University, D-60590 Frankfurt/Main, Germany. schwiebs@med.uni-frankfurt.de.
5
Pharmazentrum frankfurt/ZAFES, Clinic of the Goethe University, D-60590 Frankfurt/Main, Germany. radeke@em.uni-frankfurt.de.
6
Faculty of Pharmacy, "Gr.T.Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania. mhancianu@yahoo.com.
7
Faculty of Pharmacy, "Gr.T.Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania. oana.cioanca@gmail.com.
8
Banat University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania", 300645 Timisoara, Romania. alexa.ersilia@yahoo.ro.
9
Faculty of Pharmacy, "Victor Babeş" University of Medicine and Pharmacy, 300041 Timişoara, Romania. camelia.oprean@umft.ro.
10
Faculty of Medicine, "Victor Babeş" University of Medicine and Pharmacy, 300041 Timişoara, Romania. florinabojin@umft.ro.
11
Faculty of Pharmacy, "Victor Babeş" University of Medicine and Pharmacy, 300041 Timişoara, Romania. codrutasoica@umft.ro.
12
Faculty of Medicine, "Victor Babeş" University of Medicine and Pharmacy, 300041 Timişoara, Romania. vpaunescu@umft.ro.
13
Faculty of Pharmacy, "Victor Babeş" University of Medicine and Pharmacy, 300041 Timişoara, Romania. cadehelean@umft.ro.

Abstract

Chamomile, parsley, and celery represent major botanical sources of apigenin, a well-known flavone with chemopreventive properties. The aim of this study was to assess the phytochemical composition, antioxidant, and anti-inflammatory potential of methanol extracts obtained from chamomile, parsley, and celery collected from Romania, as well as the biological activity against A375 human melanoma and human dendritic cells. Results have shown that all three extracts are rich in polyphenolic compounds and flavonoids, and they generate a radical scavenger capacity, iron chelation potential, as well as lipoxygenase inhibition capacity. Chamomile and celery extracts present weak antiproliferative and pro-apoptotic properties in the set experimental conditions, while parsley extract draws out significant pro-apoptotic potential against A375 human melanoma cells. Parsley and chamomile extracts affected the fibroblast-like morphology of the screened tumor cell line. On the other hand, chamomile and celery extracts abrogated the expansion of LPS-activated dendritic cells, while the metabolic activity was attenuated by stimulation with celery extract; chamomile and parsley extracts had no effect upon this parameter. Chamomile and parsley extracts incubation with naive dendritic cells did not trigger cytokine secretion (TNF-alpha, IL-6, IL-10), but celery extract stimulation significantly reduced the anti-inflammatory, cytokine IL-10.

KEYWORDS:

A375 human melanoma cells; anti-inflammatory; antioxidant; celery; chamomile; dendritic cells; parsley

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