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Biomed Pharmacother. 2018 Dec;108:1244-1252. doi: 10.1016/j.biopha.2018.09.106. Epub 2018 Oct 2.

Curcumin loading potentiates the neuroprotective efficacy of Fe3O4 magnetic nanoparticles in cerebellum cells of schizophrenic rats.

Author information

1
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Students Research Committee, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2
Cancer Research Center, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3
Faculté de science, Université Paris-Sud 11, Université Paris Saclay, 91405, Orsay Cedex, France.
4
Department of Anatomical Sciences and Biology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5
Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
6
Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
7
Institute for Nanoscience and Nanotechnology, Sharif University of Technology, P.O. Box, 11365-11155, Tehran, Iran. Electronic address: simchi@sharif.edu.
8
Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Medical Nanotechnology, Faculty of Advanced Technology in Medicine, Iran University of Medical Sciences, Tehran, Iran; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address: Ashtarikhadijeh@gmail.com.

Abstract

BACKGROUND:

The aim of this study was to investigate the neurotoxic effects of Fe3O4 magnetic- CurNPs on isolated schizophrenia mitochondria of rats as an in vivo model.

METHODS:

We designed CMN loaded superparamagnetic iron oxide nanoparticles (SPIONs) (Fe3O4 magnetic- CurNPs) to achieve an enhanced therapeutic effect. The physicochemical properties of Fe3O4 magnetic- CurNPs were characterized using X-ray diffraction (XRD), and dynamic laser light scattering (DLS) and zeta potential. Further, to prove Fe3O4 magnetic- CurNPs results in superior therapeutic effects, and also, the mitochondrial membrane potential collapse, mitochondrial complex II activity, reactive oxygen species generation, ATP level, cytochrome c release and histopathology of cerebellums were determined in brains of schizophrenic rats.

RESULTS:

We showed that effective treatment with CMN reduced or prevented Fe3O4 magnetic-induced oxidative stress and mitochondrial dysfunction in the rat brain probably, as well as mitochondrial complex II activity, MMP, and ATP level were remarkably reduced in the cerebellum mitochondria of treated group toward control (p < 0.05). Therewith, ROS generation, and cytochrome c release were notably (p < 0.05) increased in the cerebellum mitochondria of treated group compared with control group.

CONCLUSION:

Taken together, Fe3O4 magnetic- CurNPs exhibits potent antineurotoxicity activity in cerebellums of schizophrenic rats. This approach can be extended to preclinical and clinical use and may have importance in schizophernia treatment in the future. To our knowledge this is the first report that provides the Fe3O4 magnetic- CurNPs could enhance the neuroprotective effects of CMN in the Schizophrenia.

KEYWORDS:

Curcumin; Iron Oxide Nanoparticles; Mitochondrial; Oxidative Stress; Rat; Schizophrenia

PMID:
30453447
DOI:
10.1016/j.biopha.2018.09.106
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