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Mol Pharm. 2019 Jan 7;16(1):1-23. doi: 10.1021/acs.molpharmaceut.8b00810. Epub 2018 Nov 30.

Gold Nanoparticles in Cancer Treatment.

Author information

1
Department of General Biophysics, Faculty of Biology and Environmental Protection , University of Lodz , 141/143 Pomorska St. , 90-236 Lodz , Poland.
2
Leibniz Institute of Polymer Research Dresden , 6 Hohe St. , 01069 Dresden , Germany.

Abstract

Colloidal gold has been studied for its potential application in medicine for centuries. However, synthesis and evaluation of various gold nanoparticles have only recently been met with a wide interest of scientists. Current studies confirm numerous advantages of nanogold over different nanomaterials, primarily due to highly optimized protocols for the production of gold nanoparticles of countless sizes and shapes, featured with unique properties. The possibility to modify the surface of nanogold particles with different targeting and functional compounds significantly broadens the range of their potential biomedical applications, with particular emphasis on cancer treatment. Functionalized gold nanoparticles exhibit good biocompatibility and controllable biodistribution patterns, which make them particularly fine candidates for the basis of innovative therapies. Considering the high amount of scientific data on nanogold, this review summarizes recent advances in the field of medical application of gold nanoparticles for the therapy of cancer.

KEYWORDS:

cancer therapy; cancer treatment; gold nanoparticles; nanogold; nanomedicine; nanotechnology

[Indexed for MEDLINE]

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