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Biosci Biotechnol Biochem. 2019 Mar;83(3):561-568. doi: 10.1080/09168451.2018.1547627. Epub 2018 Nov 19.

Propionibacterium acnes related anti-inflammation and skin hydration activities of madecassoside, a pentacyclic triterpene saponin from Centella asiatica.

Author information

1
a State Key Laboratory of Bioreactor Engineering , East China University of Science and Technology , Shanghai , People's Republic of China.
2
b Technology Center , Shanghai Inoherb Co. Ltd , Shanghai , People's Republic of China.

Abstract

Madecassoside is a major pentacyclic triterpene saponin from Centella asiatica with multiple pharmaceutical activities. In this study, we focused on its Propionibacterium acnes related anti-inflammation and skin hydration activities, both of which play important roles in skin homeostasis and barrier function. Madecassoside significantly inhibited the pro-inflammatory cytokine IL-1β, TLR2 and nuclear translocation of NF-κB in P. acnes stimulated THP-1 human monocytic cells. In addition, madecasssoside exhibited significant effects on enhancement of skin hydration through increasing the key moisturizing contributors of aquaporin-3, loricrin and involucrin in HaCaT keratinocytes as well as hyaluronan (HA) secretion in human dermal fibroblasts. The upregulation of HA synthases (HAS1, HAS2, HAS3) and inhibition to ROS formation accounted for the increment of HA content. Together, the in vitro study implied the potential medical and cosmetic application of madecassoside in skin protection.

KEYWORDS:

; Madecassoside; anti-inflammation; hyaluronan; skin hydration

PMID:
30452312
DOI:
10.1080/09168451.2018.1547627
[Indexed for MEDLINE]

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