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Nat Commun. 2018 Nov 19;9(1):4882. doi: 10.1038/s41467-018-06780-3.

Locomotion modulates specific functional cell types in the mouse visual thalamus.

Aydın Ç1,2, Couto J1,2, Giugliano M1,3,4,5,6, Farrow K1,2,3, Bonin V7,8,9,10.

Author information

1
Neuro-Electronics Research Flanders, Kapeldreef 75, 3001, Leuven, Belgium.
2
Department of Biology & Leuven Brain Institute, KU Leuven, 3000, Leuven, Belgium.
3
VIB, 3001, Leuven, Belgium.
4
Department of Biomedical Sciences, University of Antwerp, Antwerpen, Belgium.
5
Brain Mind Institute, EPFL, Lausanne, Switzerland.
6
Department of Computer Science, University of Sheffield, Sheffield, UK.
7
Neuro-Electronics Research Flanders, Kapeldreef 75, 3001, Leuven, Belgium. vincent.bonin@nerf.be.
8
Department of Biology & Leuven Brain Institute, KU Leuven, 3000, Leuven, Belgium. vincent.bonin@nerf.be.
9
VIB, 3001, Leuven, Belgium. vincent.bonin@nerf.be.
10
imec, 3001, Leuven, Belgium. vincent.bonin@nerf.be.

Abstract

The visual system is composed of diverse cell types that encode distinct aspects of the visual scene and may form separate processing channels. Here we present further evidence for that hypothesis whereby functional cell groups in the dorsal lateral geniculate nucleus (dLGN) are differentially modulated during behavior. Using simultaneous multi-electrode recordings in dLGN and primary visual cortex (V1) of behaving mice, we characterized the impact of locomotor activity on response amplitude, variability, correlation and spatiotemporal tuning. Locomotion strongly impacts the amplitudes of dLGN and V1 responses but the effects on variability and correlations are relatively minor. With regards to tunings, locomotion enhances dLGN responses to high temporal frequencies, preferentially affecting ON transient cells and neurons with nonlinear responses to high spatial frequencies. Channel specific modulations may serve to highlight particular visual inputs during active behaviors.

PMID:
30451819
PMCID:
PMC6242985
DOI:
10.1038/s41467-018-06780-3
[Indexed for MEDLINE]
Free PMC Article

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