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Chem Commun (Camb). 2018 Dec 14;54(96):13599-13602. doi: 10.1039/c8cc07583b. Epub 2018 Nov 19.

Semiconducting polymer-based nanoparticles for photothermal therapy at the second near-infrared window.

Author information

1
The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China and Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China and The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, P. R. China.
2
The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China and Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China and Liver Disease Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, P. R. China.
3
The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China and Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China and Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen 361024, P. R. China. xiaoloong.liu@gmail.com drjingfeng@126.com.
4
The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China and Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China and The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, P. R. China and Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen 361024, P. R. China. xiaoloong.liu@gmail.com drjingfeng@126.com.
5
The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China and Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China and The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, P. R. China and Liver Disease Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, P. R. China and Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen 361024, P. R. China. xiaoloong.liu@gmail.com drjingfeng@126.com.

Abstract

We designed novel diketopyrrolopyrrole polymer based nanoparticles (DPP-IID-FA), which exhibited strong light absorption and excellent photothermal conversion in the NIR optical window, and displayed high biocompatibility and photostability. Furthermore, our nanoparticles could be efficiently uptaken by cancer cells and exhibited outstanding anticancer ability both in vitro and in vivo under NIR-II laser irradiation.

PMID:
30451251
DOI:
10.1039/c8cc07583b
[Indexed for MEDLINE]

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