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Chem Commun (Camb). 2019 Jan 3;55(4):451-454. doi: 10.1039/c8cc07981a.

A clickable caging group as a new platform for modular caged compounds with improved photochemical properties.

Author information

1
Department of Biomolecular Science, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, 274-8510, Japan. furuta@biomol.sci.toho-u.ac.jp.

Abstract

A 6-bromo-7-hydroxycoumarin-4-ylmethyl (Bhc) caged compound having a click-modifiable chemical handle was designed and synthesized. This molecule was applied to the synthesis of modular caged paclitaxels (PTXs) in which additional functional units could be easily installed. This system was used to prepare water-soluble caged PTXs with improved photolysis efficiencies.

PMID:
30451249
DOI:
10.1039/c8cc07981a

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