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Yonsei Med J. 2018 Dec;59(10):1253-1256. doi: 10.3349/ymj.2018.59.10.1253.

Identification of Anti-Gerbich Antibody in an Emirati Marrow Hematopoietic Progenitor Cell Donor with Fy(a-b-) Phenotype.

Author information

1
Department of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
2
Division of Pediatric Hemato-Oncology, Department of Pediatrics, Yonsei University Health System, Yonsei University College of Medicine, Seoul, Korea.
3
Department of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. hyunok1019@yuhs.ac.

Abstract

In this study, we report a case of anti-Gerbich (Ge) alloantibody to a high-prevalence Ge antigen in a donor with Fy(a-b-) phenotype. The alloantibody was detected in an Emirati boy who was admitted to a Korean tertiary hospital for marrow hematopoietic progenitor cell donation. He did not have a history of transfusion. His blood type was A, RhD+, and findings from the antibody screening and identification test showed 2+ reactivity in all panel cells except autologous cells. We concluded that it would be very difficult to find compatible blood components for the donor and requested further tests from external laboratories. Anti-Ge2 was identified by additional tests in a foreign reference laboratory, and the Duffy genotype of the donor was FY*02/FY*02N.01 based on the Korean Rare Blood Program. Although the donor was not a Korean, as the number of foreign patients visiting Korea increases annually, there is growing interest in patients with rare blood types in the Korean population. However, there has been very little research on rare or high prevalence blood type antigen and antibody in the Korean population. Therefore, additional research in Korea is needed on rare blood group antibodies and antigens, including Ge cases.

KEYWORDS:

Duffy; Gerbich; blood group; reference laboratory; transfusion

PMID:
30450861
PMCID:
PMC6240563
DOI:
10.3349/ymj.2018.59.10.1253
[Indexed for MEDLINE]
Free PMC Article

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