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Phytother Res. 2018 Nov 19. doi: 10.1002/ptr.6228. [Epub ahead of print]

Aloysia citriodora Palau (lemon verbena) for insomnia patients: A randomized, double-blind, placebo-controlled clinical trial of efficacy and safety.

Author information

1
Department of Persian Medicine, The School of Persian Medicine, Shahid Sadoughi University of Medical Sciences, Ardakan, Yazd, Iran.
2
Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
3
Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
4
Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
5
Occupational Sleep Research Center, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.
6
Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
7
Diabetes Research Center, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
8
Department of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
9
The Research Center of the Iranian Traditional Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
10
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
11
Department of Persian Medicine, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.

Abstract

Aloysia citriodora (A. citriodora) has a long history of traditional use for sedation and treatment of insomnia in different societies. This study was carried out to assess the efficacy of A. citriodora in patients with insomnia. One hundred patients were randomly divided into two groups of A. citriodora (total essential oil 1.66 mg/10 ml and total amount of flavonoid in terms of quercetin 3.22 mg/10 ml of the syrup) and placebo. They were advised to use 10 cc of the syrups; an hour before the bedtime for a period of 4 weeks. Participants were assessed using Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI) questionnaires at the baseline and then 2 and 4 weeks after the enrollment. Mean scores of global PSQI and its four components including sleep latency, habitual sleep efficiency, daytime dysfunction, and subjective sleep quality and also ISI score in the A. citriodora group improved significantly after 4 weeks of treatment when compared with the placebo group (p < 0.001, for all of them). Also, improvement of global score of PSQI and ISI was observed in the intervention group as compared with the placebo group, 2 weeks after the enrollment (p < 0.001). The results of this study showed that oral intake of A. citriodora can be suggested as a complementary treatment for patients with insomnia.

KEYWORDS:

Aloysia citriodora; insomnia; lemon verbena; phytotherapy; sleep initiation and maintenance disorders; traditional medicine

PMID:
30450627
DOI:
10.1002/ptr.6228

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