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Best Pract Res Clin Endocrinol Metab. 2018 Oct;32(5):657-668. doi: 10.1016/j.beem.2018.05.005. Epub 2018 May 26.

Paget's disease of bone.

Author information

1
Center for Bone Quality, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: n.m.appelman-dijkstra@lumc.nl.
2
Center for Bone Quality, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: s.e.papapoulos@lumc.nl.

Abstract

Paget's disease of bone is a focal disorder of bone remodelling that progresses slowly and leads to changes in the shape and size of affected bones and to skeletal, articular and vascular complications. In some parts of the world it is the second most common bone disorder after osteoporosis though in recent years its prevalence and severity appear to decrease. The disease is easily diagnosed and effectively treated but its pathogenesis remains incompletely understood.

KEYWORDS:

Paget's disease; SQSTM1; bone turnover; genetics; zoledronate

PMID:
30449547
DOI:
10.1016/j.beem.2018.05.005

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