Format

Send to

Choose Destination
J Pharm Biomed Anal. 2019 Feb 5;164:489-495. doi: 10.1016/j.jpba.2018.10.037. Epub 2018 Oct 25.

Non-targeted metabolomic analysis on multidrug resistance hepatocellular carcinoma cell and reversal effect of annonaceous acetogenins.

Author information

1
Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing, 210023, PR China. Electronic address: mcy199202@sina.com.
2
State Key Laboratory Cultivation Base for TCM Quality and Efficacy, PR China. Electronic address: 15105179177@139.com.
3
Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, PR China. Electronic address: 13912523300@163.com.
4
Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, PR China. Electronic address: wangyaqi1008@126.com.
5
Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, PR China. Electronic address: 15077877510@163.com.
6
Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, PR China. Electronic address: shawii@126.com.
7
Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing, 210023, PR China. Electronic address: achenyongmail@163.com.
8
Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, PR China. Electronic address: liuxiao04_0@163.com.
9
Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing, 210023, PR China. Electronic address: chenjw695@126.com.
10
Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing, 210023, PR China. Electronic address: lixiang_8182@163.com.

Abstract

Multidrug-resistance (MDR) has been shown to play a critical role in the development of many diseases. In this study, we used metabolomic method to evaluate the MDR in hepatocellular carcinoma, and investigate regulatory of annonaceous acetogenins on MDR of hepatocellular carcinoma. Multivariate statistical analysis revealed that the MDR of SMMC 7721 together with changes in glutathione metabolism, arginine and proline metabolism, sphingolipid metabolism. Annonaceous acetogenins impact these metabolism pathways. Metabolic pathway analysis coupled with stoichiometry analysis can be an effective tool to understand MDR mechanism and to potentially find new MDR reversal agents.

KEYWORDS:

Annonaceous acetogenins; Hepatocellular carcinoma; Metabolomics; Multidrug resistance

PMID:
30448539
DOI:
10.1016/j.jpba.2018.10.037
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center