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Drug Discov Today. 2019 Feb;24(2):377-381. doi: 10.1016/j.drudis.2018.11.008. Epub 2018 Nov 15.

Accelerating pharmaceutical structure-guided drug design: a successful model.

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Hauptman-Woodward Medical Research Institute, Buffalo, NY 14203 USA; Industrial Macromolecular Crystallography Association - Collaborative Access Team (IMCA-CAT), Advanced Photon Source, Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL, 60439 USA.
AbbVie Inc. 1 North Waukegan Road, North Chicago, IL 60064-6098, USA. Electronic address:


The impact and value of structure-based drug design to pharmaceutical discovery across the industry are now undeniable, with many break-through therapies on the market that are structure based in nature. Enabling the structural research is the Industrial Macromolecular Crystallography Association-Collaborative Access Team (IMCA-CAT), formed over 25 years ago as a world-class research facility at the synchrotron at Argonne National Laboratory. What makes IMCA-CAT unique is the strategy of the founding consortium to comprehensively provide for the evolving needs of industry in one facility. This includes year-round high-quality data, capabilities that match target portfolios, throughput and capacity that are never limiting, and unfailing security. Here, we illuminate the unique capabilities offered by IMCA-CAT and instruct how all industrial organizations can access this facility.

[Indexed for MEDLINE]

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