Format

Send to

Choose Destination
Semin Cancer Biol. 2018 Nov 16. pii: S1044-579X(18)30073-7. doi: 10.1016/j.semcancer.2018.11.001. [Epub ahead of print]

KDM5B is a master regulator of the H3K4-methylome in stem cells, development and cancer.

Author information

1
Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA; Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA.
2
Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA; Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address: benjamin.kidder@wayne.edu.

Abstract

Epigenetic regulation of chromatin plays a critical role in controlling stem cell function and tumorigenesis. The histone lysine demethylase, KDM5B, which catalyzes the demethylation of histone 3 lysine 4 (H3K4), is important for embryonic stem (ES) cell differentiation, and is a critical regulator of the H3K4-methylome during early mouse embryonic pre-implantation stage development. KDM5B is also overexpressed, amplified, or mutated in many cancer types. In cancer cells, KDM5B regulates expression of oncogenes and tumor suppressors by modulating H3K4 methylation levels. In this review, we examine how KDM5B regulates gene expression and cellular fates of stem cells and cancer cells by temporally and spatially controlling H3K4 methylation levels.

KEYWORDS:

Cancer; Chromatin; Differentiation; Embryonic stem cells; Epigenetics; Gene expression; H3K4me3; Histone demethylase; KDM5B; Pluripotent

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center