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Int J Biol Macromol. 2019 Feb 15;123:866-877. doi: 10.1016/j.ijbiomac.2018.11.108. Epub 2018 Nov 14.

Fluorine-ion-releasing injectable alginate nanocomposite hydrogel for enhanced bioactivity and antibacterial property.

Author information

1
Department of Materials Science and Engineering, Seoul National University, Seoul, South Korea.
2
Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, South Korea.
3
Department of Materials Science and Engineering, Seoul National University, Seoul, South Korea; Biomedical Implant Convergence Research Center, Advanced Institutes of Convergence Technology, Suwon, South Korea.
4
Department of Materials Science and Engineering, Seoul National University, Seoul, South Korea. Electronic address: jsh528@snu.ac.kr.

Abstract

The creation of a moist environment and promotion of cell proliferation and migration together with antibacterial property are critical to the wound-healing process. Alginate (Alg) is an excellent candidate for injectable wound dressing materials because it can form a gel in a mild environment. Taking advantage of its gelation property, an injectable nano composite hydrogel containing nano-sized (about 90 nm) calcium fluoride (CaF2) particles was developed using in-situ precipitation process. The amount of released fluorine (F-) ion from the nanocomposite hydrogel increased with increasing CaF2 content inside the composite hydrogel and the ions stimulated both the proliferation and migration of fibroblast cells in vitro. The antibacterial property of the composite hydrogel against E. coli and S. aureus was confirmed through colony formation test where the number of bacterial colonies significantly decreased compared to Alg hydrogel. The in vivo results based on a full-thickness wound model showed that the nanocomposite hydrogel effectively enhanced the deposition of the extracellular matrix compared to that of the Alg hydrogel. This study demonstrates the potential of this nanocomposite hydrogel as a bioactive injectable wound-dressing material with the ability to inhibit bacterial growth and stimulate cell proliferation and migration for accelerated wound healing.

KEYWORDS:

Alginate; Antibacterial; Calcium fluoride; In situ precipitation; Nanocomposite hydrogel; Wound dressings

PMID:
30447366
DOI:
10.1016/j.ijbiomac.2018.11.108
[Indexed for MEDLINE]

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