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Hepatol Int. 2018 Nov 16. doi: 10.1007/s12072-018-9910-x. [Epub ahead of print]

The effects of curcumin on the metabolic parameters of non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials.

Author information

1
Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, No. 157, Xi Wu Road, Xi'an, Shanxi, People's Republic of China.
2
Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, No. 157, Xi Wu Road, Xi'an, Shanxi, People's Republic of China. liunafmmu@163.com.
3
Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, No. 157, Xi Wu Road, Xi'an, Shanxi, People's Republic of China. jinhaiwang@hotmail.com.

Abstract

AIMS:

Evidence indicates that curcumin seems to improve outcomes in non-alcoholic fatty liver disease (NAFLD). A meta-analysis was performed to evaluate the effects of curcumin inNAFLD.

METHODS:

We searched PubMed, EMBASE, and the Cochrane Library from inception through March 2018 to identify randomized controlled trials (RCTs) evaluating the role of curcumin inNAFLD. The mean difference (MD) and 95% confidence interval (CI) were calculated.

RESULTS:

Four RCTs with a total of 229 NAFLD patients were included. Curcumin was more likely to lower LDL-C, triglycerides, FBS, HOMA-IR, weight and AST levels compared with placebo, and the difference was statistically significant [MD = - 27.02, 95% CI (- 52.30, - 1.74); MD = - 33.20, 95% CI (- 42.30, - 24.09); MD = - 5.63, 95% CI (- 10.36, - 0.90); MD = - 0.53, 95% CI (- 1.00, - 0.05); MD = - 2.27, 95% CI (- 3.11, - 1.44); MD = - 7.43, 95% CI (- 11.31, - 3.54), respectively]. However, the beneficial effect of curcumin did not achieve statistical significance in lowering total cholesterol, HDL-C, HbA1c, ALT or insulin levels [MD = - 30.47,95% CI (- 60.89. - 0.06); MD = - 0.98, 95% CI (- 2.88, 0.92); MD = - 0.41, 95% CI (- 1.41, 0.59); MD = - 6.02, 95% CI (- 15.61, 3.57); MD = - 0.92, 95% CI (- 2.33, 0.49)].

CONCLUSIONS:

Curcumin is effective in lowering LDL-C, triglycerides, FBS, HOMA-IR, weight, and AST levels in NAFLD patients, and it is well tolerated. Further RCTs are required to confirm our findings.

KEYWORDS:

Curcumin; Meta-analysis; Non-alcoholic fatty liver disease

PMID:
30446932
DOI:
10.1007/s12072-018-9910-x

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