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Immunobiology. 2019 Jan;224(1):110-115. doi: 10.1016/j.imbio.2018.10.002. Epub 2018 Oct 19.

Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans.

Author information

1
School of Medical and Health Sciences, Edith Cowan University, Joondalup, 6027, Australia; School of Population and Global Health, University of Western Australia, Nedlands, 6009, Australia.
2
Department of Immunology, Institute of Zoology, Faculty of Biology, University of Warsaw, Warsaw, 02-096, Poland.
3
Genos Glycoscience Research Laboratory, Zagreb, 10000, Croatia.
4
Genos Glycoscience Research Laboratory, Zagreb, 10000, Croatia; Faculty of Science, University of Split, Split, 21000, Croatia; Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10000, Zagreb, Croatia.
5
School of Medical and Health Sciences, Edith Cowan University, Joondalup, 6027, Australia; Key Municipal Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, 100069, China.
6
School of Population and Global Health, University of Western Australia, Nedlands, 6009, Australia; Busselton Population Medical Research Institute, Perth, 6000, Australia.
7
School of Population and Global Health, University of Western Australia, Nedlands, 6009, Australia; Busselton Health Study Centre, Busselton Population Medical Research Institute, Busselton, 6280, Australia.
8
School of Medical and Health Sciences, Edith Cowan University, Joondalup, 6027, Australia; School of Biomedical Sciences, Faculty of Health Science, Curtin University, Bentley, 6102, Australia; Co-operative Research Centre for Mental Health, Carlton South, 3053, Australia.
9
Genos Glycoscience Research Laboratory, Zagreb, 10000, Croatia; Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10000, Zagreb, Croatia. Electronic address: glauc@pharma.hr.
10
School of Medical and Health Sciences, Edith Cowan University, Joondalup, 6027, Australia; Key Municipal Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, 100069, China; Taishan Medical University, Taian, 271016, China. Electronic address: wei.wang@ecu.edu.au.

Abstract

BACKGROUND:

Increased body fat may be associated with an increased risk of developing an underlying pro-inflammatory state, thus leading to greater risk of developing certain chronic conditions. Immunoglobulin G has the ability to exert both anti- and pro-inflammatory effects, and the N-glycosylation of the fragment crystallisable portion is involved in mediating this process. Body mass index, a rudimentary yet gold standard indication for body fat, has been shown to be associated with agalactosylated immunoglobulin G N-glycans.

AIM:

We aimed to determine the association between increased body fat and the immunoglobulin G glycosylation features, comparing body mass index to other measures of body fat distribution.

METHODS:

We investigated a sample of 637 community-based 45-69 year olds, with mixed phenotypes, residing in Busselton, Western Australia. Body mass index and the waist-to-hip and waist-to-height ratios were calculated using anthropometry, while dual-energy x-ray absorptiometry was performed to gain an accurate measure of total and area specific body fat. Serum immunoglobulin GN-glycans were analysed by ultra-performance liquid chromatography.

RESULTS:

Twenty-two N-glycan peaks were found to be associated with at least one of the fat measures. While the previous association of body mass index to agalactosylated immunoglobulin G was replicated, measures of central adiposity explained the most variation in the immunoglobulin G glycome.

CONCLUSION:

Central adiposity is associated with an increased pro-inflammatory fraction of immunoglobulin G, suggesting that the android/gynoid ratio or waist-to-height ratio instead be considered when controlling for adiposity in immunoglobulin G glycome biomarker studies.

KEYWORDS:

Body mass index; Central adiposity; Glycosylation; Immunoglobulin G; Pro-inflammation

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