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Retrovirology. 2018 Nov 16;15(1):73. doi: 10.1186/s12977-018-0455-9.

Antibody-mediated prevention and treatment of HIV-1 infection.

Gruell H1,2, Klein F3,4,5.

Author information

1
Laboratory of Experimental Immunology, Institute of Virology, University Hospital Cologne, Fürst-Pückler-Str. 56, 50935, Cologne, Germany.
2
German Center for Infection Research, Partner-Site Bonn-Cologne, Cologne, Germany.
3
Laboratory of Experimental Immunology, Institute of Virology, University Hospital Cologne, Fürst-Pückler-Str. 56, 50935, Cologne, Germany. florian.klein@uk-koeln.de.
4
German Center for Infection Research, Partner-Site Bonn-Cologne, Cologne, Germany. florian.klein@uk-koeln.de.
5
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. florian.klein@uk-koeln.de.

Abstract

Novel broadly neutralizing antibodies targeting HIV-1 hold promise for their use in the prevention and treatment of HIV-1 infection. Pre-clinical results have encouraged the evaluation of these antibodies in healthy and HIV-1-infected humans. In first clinical trials, highly potent broadly neutralizing antibodies have demonstrated their safety and significant antiviral activity by reducing viremia and delaying the time to viral rebound in individuals interrupting antiretroviral therapy. While emerging antibody-resistant viral variants have indicated limitations of antibody monotherapy, strategies to enhance the efficacy of broadly neutralizing antibodies in humans are under investigation. These include the use of antibody combinations to prevent viral escape, antibody modifications to increase the half-life and the co-administration of latency-reversing agents to target the cellular reservoir of HIV-1. We provide an overview of the results of pre-clinical and clinical studies of broadly HIV-1 neutralizing antibodies, discuss their implications and highlight approaches for the ongoing advancement into humans.

KEYWORDS:

(S)HIV animal models; Clinical trials; Fc-mediated activity; HIV-1 broadly neutralizing antibodies; Immunotherapy; Neutralization; Passive immunization

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