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Int J Mol Sci. 2018 Nov 15;19(11). pii: E3604. doi: 10.3390/ijms19113604.

A Graded Multifunctional Hybrid Scaffold with Superparamagnetic Ability for Periodontal Regeneration.

Author information

1
Institute of Science and Technology for Ceramics-National Research Council (ISTEC-CNR), Via Granarolo 64, 48018 Faenza, Italy. simone.sprio@istec.cnr.it.
2
Institute of Science and Technology for Ceramics-National Research Council (ISTEC-CNR), Via Granarolo 64, 48018 Faenza, Italy. elisabetta.campodoni@istec.cnr.it.
3
Institute of Science and Technology for Ceramics-National Research Council (ISTEC-CNR), Via Granarolo 64, 48018 Faenza, Italy. monica.sandri@istec.cnr.it.
4
Institute of Science and Technology for Ceramics-National Research Council (ISTEC-CNR), Via Granarolo 64, 48018 Faenza, Italy. lorenzo.preti@istec.cnr.it.
5
Laboratory of Bio-Inspired & Graphene Nanomechanics, Department of Civil, Environmental and Mechanical Engineering, University of Trento, Via Mesiano 77, 38123 Trento, Italy. lorenzo.preti@istec.cnr.it.
6
Otto Schott Institute of Materials Research, Friedrich Schiller University, Löbdergraben 32, 07743 Jena, Germany. tobias_keppler@yahoo.de.
7
Otto Schott Institute of Materials Research, Friedrich Schiller University, Löbdergraben 32, 07743 Jena, Germany. frank.mueller@uni-jena.de.
8
Laboratory of Bio-Inspired & Graphene Nanomechanics, Department of Civil, Environmental and Mechanical Engineering, University of Trento, Via Mesiano 77, 38123 Trento, Italy. nicola.pugno@unitn.it.
9
School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK. nicola.pugno@unitn.it.
10
Ket-Lab, Edoardo Amaldi Foundation, Italian Space Agency, Via del Politecnico, 00133 Rome, Italy. nicola.pugno@unitn.it.
11
Institute of Science and Technology for Ceramics-National Research Council (ISTEC-CNR), Via Granarolo 64, 48018 Faenza, Italy. anna.tampieri@istec.cnr.it.

Abstract

The regeneration of dental tissues is a still an unmet clinical need; in fact, no therapies have been completely successful in regenerating dental tissue complexes such as periodontium, which is also due to the lack of scaffolds that are able to guide and direct cell fate towards the reconstruction of different mineralized and non-mineralized dental tissues. In this respect, the present work develops a novel multifunctional hybrid scaffold recapitulating the different features of alveolar bone, periodontal ligament, and cementum by integrating the biomineralization process, and tape casting and electrospinning techniques. The scaffold is endowed with a superparamagnetic ability, thanks to the use of a biocompatible, bioactive superparamagnetic apatite phase, as a mineral component that is able to promote osteogenesis and to be activated by remote magnetic signals. The periodontal scaffold was obtained by engineering three different layers, recapitulating the relevant compositional and microstructural features of the target tissues, into a monolithic multifunctional graded device. Physico-chemical, morphological, and ultrastructural analyses, in association with preliminary in vitro investigations carried out with mesenchymal stem cells, confirm that the final scaffold exhibits a good mimicry of the periodontal tissue complex, with excellent cytocompatibility and cell viability, making it very promising for regenerative applications in dentistry.

KEYWORDS:

biomimetic hybrid scaffold; biomineralization; collagen; electrospinning; periodontal regeneration; superparamagnetic hydroxyapatite

PMID:
30445700
DOI:
10.3390/ijms19113604
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