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Nucleic Acids Res. 2019 Jan 8;47(D1):D601-D606. doi: 10.1093/nar/gky967.

RNAct: Protein-RNA interaction predictions for model organisms with supporting experimental data.

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Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona 08003, Spain.
Institució Catalana de Recerca i Estudis Avançats (ICREA), 23 Passeig Lluís Companys, Barcelona 08010, Spain.
Universitat Pompeu Fabra (UPF), Department of Experimental and Health Sciences, Barcelona 08003, Spain.
Department of Biology 'Charles Darwin', Sapienza University of Rome, P.le A. Moro 5, Rome 00185, Italy.


Protein-RNA interactions are implicated in a number of physiological roles as well as diseases, with molecular mechanisms ranging from defects in RNA splicing, localization and translation to the formation of aggregates. Currently, ∼1400 human proteins have experimental evidence of RNA-binding activity. However, only ∼250 of these proteins currently have experimental data on their target RNAs from various sequencing-based methods such as eCLIP. To bridge this gap, we used an established, computationally expensive protein-RNA interaction prediction method, catRAPID, to populate a large database, RNAct. RNAct allows easy lookup of known and predicted interactions and enables global views of the human, mouse and yeast protein-RNA interactomes, expanding them in a genome-wide manner far beyond experimental data (

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