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Free Radic Biol Med. 2019 Jan;130:419-425. doi: 10.1016/j.freeradbiomed.2018.11.011. Epub 2018 Nov 14.

Urinary oxidative stress biomarkers and accelerated time to spontaneous delivery.

Author information

1
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
2
Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.
3
Department of Pediatrics, Seattle Children's Research Institute, University of Washington, Seattle, WA 98101, USA; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98101, USA.
4
Department of Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USA.
5
Department of Epidemiology & Community Health, University of Minnesota, Minneapolis, MN 55454, USA.
6
Departments of Psychiatry and Pediatrics, University of California at San Francisco, San Francisco, CA 94118, USA.
7
Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
8
Department of Maternal-Fetal Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
9
Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
10
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Electronic address: Kelly.Ferguson2@nih.gov.

Abstract

BACKGROUND:

Oxidative stress has been implicated in numerous birth outcomes, including spontaneous preterm birth. However, the relationship with presentation at delivery has been less well studied. We assessed the relationship between oxidative stress biomarkers and gestational duration with a focus on spontaneous presentation for delivery.

METHODS:

Our sample included 740 women from a multi-center prospective cohort study, recruited from 2010 to 2012. Resultant measures of oxidative stress in pregnancy prostaglandin F (PGF), 8-iso-prostaglandin F (8-iso-PGF), and the primary 8-iso-PGF metabolite were measured in third trimester urine samples. Information on presentation for delivery was abstracted from medical records. We examined associations with preterm birth using adjusted logistic models. Time to event (overall delivery and spontaneous delivery) was examined using adjusted accelerated failure time models.

RESULTS:

The 8-iso-PGF metabolite was associated with increased odds of overall preterm birth (OR: 1.44 [95% CI: 1.00, 2.06]), and the association with spontaneous preterm birth was similar in magnitude but not statistically significant (OR: 1.45 [95% CI: 0.96, 2.20]). We did not detect associations between other biomarkers and preterm birth, or between biomarkers and timing of overall or spontaneous delivery in accelerated failure time models.

CONCLUSIONS:

Our data suggest that increased oxidative stress, as indicated by the 8-iso-PGF metabolite, may be associated with preterm birth. In contrast to previous studies, associations were similar among individuals with spontaneous versus non-spontaneous presentation for delivery.

KEYWORDS:

Isoprostanes; Oxidative stress; Preterm birth; Prostaglandin; Spontaneous labor

PMID:
30445128
PMCID:
PMC6331226
[Available on 2020-01-01]
DOI:
10.1016/j.freeradbiomed.2018.11.011

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