Oxygen Starvation Unmasks a Killer

Cell Chem Biol. 2018 Nov 15;25(11):1313-1314. doi: 10.1016/j.chembiol.2018.10.028.

Abstract

In this issue of Cell Chemical Biology, Jacobsen et al. (2018) investigate the hypoxia selectivity of two cyclolipodepsipeptide natural products bearing a 4-amido-2,4-pentadienoate warhead. A switch in the cell death pathway under hypoxic conditions is observed, suggesting these electrophilic natural products have potential as a prodrug-free approach for treating hypoxic tumors.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Cell Hypoxia
  • Humans
  • Hypoxia
  • Mitochondria
  • Neoplasms*
  • Oxygen*

Substances

  • Oxygen